Ryanodine receptors: waking up from refractoriness

Ryanodine receptors: waking up from refractoriness.

Ca2+-induced Ca2+ release (CICR) from the sarcoplasmic reticulum (SR) via ryanodine receptors (RyRs) ultimately governs cardiac muscle force and can be considered as an amplification system for cardiac Ca2+ signals. CICR is initiated by Ca2+ influx via voltagedependent L-type Ca2+ channels. Unlike skeletal muscle fibres, each cardiac myocyte can produce an amount of force (and a Ca2+ transient)...

Waking Up from the American Dream

For eight consecutive months in 2006, Colorado had a greater number of home foreclosures than any other state in the country. Largely attributable to the Denver housing market, this dubious statewide distinction raises questions as to the foreclosure rates and trends in communities beyond the state’s capitol, where little analytical research has been conducted. This project delves into the loca...

Waking up to narcolepsy.

Narcolepsy with cataplexy, certainly one of the most fascinating problems in medicine, always seemed (to us) an unlikely candidate for an autoimmune or infectious etiology. In typical cases, the CSF is bland and MRI unrevealing. Powerful evidence (summarized in reference 1) that abnormalities of the hypocretin system contribute to narcolepsy came initially from genetic studies revealing that ca...

Ryanodine receptors

ISSN: 1933-6950 (Print) 1933-6969 (Online) Journal homepage: http://www.tandfonline.com/loi/kchl20 Ryanodine receptors Mounia Chami & Frédéric Checler To cite this article: Mounia Chami & Frédéric Checler (2014) Ryanodine receptors, Channels, 8:3, 168-168, DOI: 10.4161/chan.29000 To link to this article: http://dx.doi.org/10.4161/chan.29000 Copyright © 2014 Landes Bioscience Published online: 2...

Waking up to Global Warming